A medical profesisonal administering an injection to a patient's inner arms.

Did you know that medical research has traced many visible signs of aging back to volume loss? According to the American Board of Cosmetic Surgery, fine lines appear around the nose and mouth when facial tissues thin out and cheeks look sunken. As a result, individuals often seek aesthetic treatments for their skin concerns.

Injectable dermal fillers are among the many aesthetic options available, offering a non-surgical intervention for individuals. These fillers can replace lost volume, contour facial features, and smooth the signs of aging to restore a youthful appearance. What sets Profhilo and Radiesse dermal fillers apart is their approach, which starts in the skin’s deep layers.

This article will analyze the differences between Profhilo vs Radiesse, their compositions, mechanisms of action, clinical applications, benefits, and ideal patient profiles.

Key Takeaways

  • While Profhilo and Radiesse differ from their main active ingredient, their formulations integrate into the skin and stimulate collagen and elastin production.
  • Medical professionals should discuss the treatment procedure, benefits, and potential risks with patients during a thorough consultation.
  • While both injectables deliver significant improvement, they specifically focus on different aspects of facial rejuvenation.
  • It’s worth noting that Profhilo and Radiesse injectables can cause temporary side effects after their treatment.

Understanding Profhilo and Radiesse

Two medical syringes and vials.

Over the years, injectable dermal fillers have become popular as an effective non-surgical solution to address signs of aging and other skin concerns. These dermal fillers can offer various facial rejuvenation procedures, such as volumizing, contouring, and hydration. Many injectable brands have arrived in the aesthetic market with different primary active ingredients.

Profhilo injections capitalize on the potency of hyaluronic acid (HA). This injectable works beneath the skin, utilizing NAHYCO technology to create a unique HA gel substance. Using the Profhilo BAP technique, the injections stimulated the skin cell receptors to counteract skin laxity, improving and restoring skin firmness and quality.

On the other hand, Radiesse dermal fillers use calcium hydroxylapatite (CaHA). This substance makes Radiesse injectables unique aesthetic treatments for individuals. It provides immediate, natural-looking results while stimulating collagen and elastin production for the skin’s needs.

While these dermal fillers differ from their main active ingredient, Profhilo and Radiesse formulations integrate into the skin and stimulate the production of collagen and elastin, two critical components of skin quality. It’s worth noting that patients must consult their trusted medical professionals to determine the best treatment choice for their needs, goals, and health.

Clinical Applications

A healthcare provider administering a facial injection to a patient.

During a thorough consultation, medical professionals should discuss the treatment procedure, benefits, and potential risks with patients. This allows them to understand the suitable treatment choice and make informed decisions for their aesthetic procedure.

Profhilo injections have more treatment areas than Radiesse injectables. The most common areas of Profhilo treatment include the face and neck, but it can also effectively treat skin laxity in the décolletage, hands, arms, knees, and abdomen. Profhilo can help counteract skin laxity, remodel aging and sagging tissue, and deliver a significant tightening or lifting effect. Medical professionals must know the contraindications of Profhilo injections.

  • Patients with hypersensitivity to hyaluronan properties and Profhilo formulation.
  • Patients with skin infections or diseases at or near the injection site.
  • Pregnant women, breastfeeding women, and children 18 and below must avoid Profhilo injections.

Meanwhile, the US Food and Drug Administration has approved Radiesse injectables for numerous facial regions and body parts. Medical professionals can utilize Radiesse and Radiesse + on the jawline for moderate to severe contouring.

Other Radiesse treatment areas include the lower face (smile lines, corners of the mouth, marionette lines, pre-jowl folds, and chin wrinkles) and the hands (restoring volume loss and minimizing the visibility of veins and tendons). Moreover, understanding Radiesse contraindications can ensure a safe and effective treatment.

  • Patients with severe allergies manifested by a history of anaphylaxis or history or presence of multiple severe allergies.
  • Patients with known hypersensitivity to any of the components.
  • Patients with bleeding disorders.

Comparative Analysis of Benefits and Drawbacks

Patients should understand a procedure’s benefits and drawbacks. Medical professionals can provide them with comprehensive information about Profhilo and Radiesse treatments. While both injectables deliver significant improvement, they specifically focus on different aspects of facial rejuvenation.

After two to three weeks of Profhilo injection treatment, patients can expect improved skin hydration with a natural glow. After the full protocol, they should achieve optimal results with visible skin lifting and improvement in overall skin texture and radiance.

However, it’s worth noting that Profhilo injections can cause temporary side effects after the treatment. These symptoms may subside over time once the body adapts to the medicine. These Profhilo side effects may occur at the injection site, and when they persist, immediately seek medical attention.

  • Bumps at the Injection Site
  • Post-treatment Discomfort
  • Redness
  • Swelling
  • Pain
  • Itching
  • Bruising or Tenderness at the Treatment Site

Radiesse injectables can help smooth out lines and wrinkles, immediately contour the treated areas, and restore one’s youthful appearance. These injections smoothen moderate to severe facial wrinkles and folds and correct volume loss in the back of the hands.

Like Profhilo, patients can expect common side effects after their Radiesse treatments. These side effects may resolve after a few days or weeks; however, patients must seek medical attention if symptoms persist.

  • Bruising
  • Redness
  • Swelling
  • Pain
  • Itching at the Injection Site

Expert Insights and Clinical Studies

A healthcare provider administering a facial injection to a patient.

A safety assessment by Cassuto et al. (2020) reported minor events after Profhilo injections. This result highlights the injectable’s high tolerability and safety for patients. Another study exhibited that low- and high-molecular-weight hyaluronic acid helped improve facial skin quality and deliver its bio-remodeling purpose.

In a study by de Almeida et al. (2023), two Radiesse sessions showed that individuals well-tolerated the injectable. It improved necklines, neck laxity, and dermal thickness in adult women with mild and moderate cervical aging. Moreover, an expert consensus study supports and guides using Radiesse as a biostimulatory agent for face and body rejuvenation.

Conclusion

Profhilo and Radiesse are potent and effective dermal filler solutions for skin rejuvenation and quality. While both injectables offer safety and efficacy, Profhilo and Radiesse capitalize on different active ingredients: hyaluronic acid and calcium hydroxylapatite. They also have similar mechanisms of action, stimulating collagen and elastin production for optimal outcomes that help patients achieve their aesthetic goals.

FAQs

  1.  What are the main differences between Profhilo and Radiesse?

Profhilo utilizes hyaluronic acid (HA) to improve and restore skin firmness and quality. At the same time, Radiesse uses calcium hydroxylapatite (CaHA) to provide immediate, natural-looking results and stimulate collagen and elastin production.

  1. What are the common treatment areas for Profhilo and Radiesse?

Profhilo is commonly used on the face, neck, décolletage, hands, arms, knees, and abdomen to counteract skin laxity and deliver a tightening or lifting effect. Radiesse is approved for use on the jawline, lower face, and hands to contour and restore volume.

  1.  What are the potential side effects of Profhilo injections?

Temporary side effects of Profhilo injections may include bumps at the injection site, post-treatment discomfort, redness, swelling, pain, itching, and bruising. These symptoms typically subside as the body adapts to the treatment.

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References

  1. Injectable Fillers Guide. (2014, July 11). American Board of Cosmetic Surgery. https://www.americanboardcosmeticsurgery.org/procedure-learning-center/non-surgical/injectable-fillers-guide/
  2. FAQs. (n.d.). Radiesse Injectables. Retrieved May 23, 2024, from https://radiesse.com/faqs/
  3. Cassuto, D., Delledonne, M., Zaccaria, G., Illiano, I., Giori, A. M., & Bellia, G. (2020). Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. BioMed research international, 2020, 8159047. https://doi.org/10.1155/2020/8159047