According to the latest American Society of Plastic Surgeons report, neuromodulator injections ranked first among minimally invasive procedures, with over 8.7 million performed in 2022. This outstanding number highlights the trust patients and professionals have in these injections to achieve facial rejuvenation and a youthful appearance.
Neuromodulator injections utilize botulinum toxin to offer wrinkle-relaxing shots in the facial regions. These injections can provide a smoother facial look to individuals, targeting the signs of aging. Dysport and Jeuveau stand out with their proven safety and efficacy in smoothing frown lines and wrinkles among many brand-name injections.
In this article, we will compare Dysport vs Jeuveau and examine their mechanisms of action, formulations, and safety profiles.
Key Takeaways
- Dysport and Jeuveau work by blocking the release of acetylcholine, the neurotransmitter responsible for muscle contractions.
- The primary difference between Dysport and Jeuveau lies in their protein structures and the technologies used in their manufacturing process.
- The reported onset of Dysport is typically two to three days, with final results evident around a few more days post-injection.
- Individuals must seek medical professionals’ guidance to ensure a safe and effective treatment for their facial aging signs.
- Patient satisfaction rates are crucial to the effectiveness and acceptability of treatments like Dysport and Jeuveau.
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Introduction to Dysport and Jeuveau
Dysport and Jeuveau injections have received the US Food and Drug Administration approval to temporarily treat moderate to severe frown lines in adults. Both utilize botulinum toxin type A, temporarily paralyzing muscles and reducing wrinkle appearance.
Dysport or abobotulinumtoxinA can address and smoothen the vertical lines between the eyebrows. Medical professionals also use this treatment to smoothen crow’s feet or use Dysport on forehead creases.
Meanwhile, Evolus’ Jeuveau offers the newest commercial injectable botulinum toxin type A formulation. It specifically targets the dynamic wrinkles found between the eyebrows. These expression wrinkles often form when individuals make facial expressions like smiling or frowning.
Pharmacological Properties
Dysport and Jeuveau, like other botulinum toxin products, have similar mechanisms of action. When adequately administered by licensed healthcare providers, they can maximize the effects of these products. Both injections are neuromuscular blocking agents.
They work by blocking the release of acetylcholine, the neurotransmitter responsible for muscle contractions. When providers administer Jeuveau or Dysport, they block these nerve signals from reaching particular muscles, temporarily halting muscle movement or activity. This results in the reduction of the appearance of wrinkles in the area.
Both pharmacokinetics mentioned that using currently available analytical technology, Dysport and Jeuveau are impossible to detect in the peripheral blood following intramuscular injection at the recommended doses.
Formulation Characteristics
Dysport, known as abobotulinumtoxinA, comprises botulinum toxin type A, human albumin, and lactose. Dysport supplies its injections with 300 or 500 Units of lyophilized powder in single-dose vials, which providers must reconstitute with a preservative-free 0.9% sodium chloride injection.
Jeuveau, known as prabotulinumtoxinA-xvfs, contains inactive ingredients such as human serum albumin and sodium chloride. It comprises 900 kDa purified botulinum toxin formula type A and is supplied in a single-dose 100-unit vial, which requires reconstitution with preservative-free 0.9% sodium chloride injection.
Dysport and Jeuveau may have similar mechanisms of action but differ in their formulations. Their primary difference lies in their protein structures and the technologies used in their manufacturing process.
Onset and Duration of Action
The reported onset of Dysport is typically two to three days, with final results evident around a few more days post-injection. According to Dysport, some patients may notice significant improvements sooner. On the other hand, Jeuveau has shown swifter results due to the formulation’s use of smaller and more uniform proteins.
- Dysport’s Duration of Action: It’s worth noting that the rejuvenating effects of a Dysport injection may last up to five months. This means patients can enjoy a refreshed and youthful appearance for an extended period post-treatment.
- Jeuveau’s Duration of Action: Meanwhile, Jeuveau’s effects are similar to Dysport’s. They can last up to five months, and individual responses may vary.
Clinical Efficacy
Dysport and Jeuveau are both effective neuromodulators used for aesthetic purposes. They show effects in two to three days, with these injections lasting about three to five months. Dysport and Jeuveau have specific indications for effectively treating moderate to severe glabellar lines. It significantly improves frown lines and crow’s feet, lasting approximately five months.
Furthermore, medical professionals may also use Dysport or Jeuveau to treat crow’s feet, which are wrinkles on the side of the eyes. These injections can also help smooth out the aging signs around the eyes and on the forehead, delivering a youthful look for the patients.
Individuals must seek medical professionals’ guidance to ensure a safe and effective treatment for their facial aging signs. They will know the proper dosing regimen and administration technique to maximize the benefits of Jeuveau and Dysport on forehead, frown lines, crow’s feet, and subtle eyebrow lift.
Practical Considerations
Medical professionals know the appropriate Jeuveau and Dysport dosing for managing the glabellar lines. The typical dose of Jeuveau injections requires 4 Units in each of the five sites for a total of 20 Units. Meanwhile, Dysport dosing requires 10 Units each for the five sites, which is 50 Units for glabellar lines.
Dysport and Jeuveau require intramuscular injection into the targeted facial muscles using the appropriate-sized needle. Healthcare providers must administer shots into each of the five injection sites around the frown lines. These injection procedures usually last for 10 to 15 minutes.
Medical professionals can help individuals determine the best treatment option for glabellar lines. They can consider various factors, such as cost, the severity of the glabellar condition, current medications, other diseases, and overall health. A thorough consultation allows providers to create a personalized treatment plan for each patient.
Safety Profiles and Adverse Effects
Like other therapies, Dysport and Jeuveau can cause temporary side effects in individuals after treatment. These side effects may range from mild to moderate and can subside once the body fully adapts to the medication. Moreover, these injections also have rare occurrences of adverse effects.
- Common Adverse Effects of Dysport: Nasopharyngitis, headache, injection site pain, injection site reaction, upper respiratory tract infection, eyelid edema, eyelid ptosis, sinusitis, nausea, and blood present in urine.
- Common Adverse Effects of Jeuveau: Headache, eyelid ptosis, upper respiratory tract infection, increased white blood cell count.
Patients should immediately contact their trusted healthcare providers for medical attention when these symptoms occur. Immediate medical attention can help avoid further complications and severe health risks. Moreover, Dysport and Jeuveau are generally well-tolerated by most individuals but have a few contraindications.
- Contraindications of Dysport: Hypersensitivity to any botulinum toxin product or excipients, cow’s milk protein, and infection at the proposed injection site(s).
- Contraindications of Jeuveau: Hypersensitivity to any botulinum toxin preparation or any of the components in the formulation and infection at the injection site.
Patient Satisfaction Rates
Patient satisfaction rates are crucial to the effectiveness and acceptability of treatments like Dysport and Jeuveau. Various factors, including treatment outcomes, side effects, and individual patient expectations, can influence them.
- Patient Satisfaction Rates with Dysport: Clinical studies have shown high patient satisfaction. In a study involving 120 individuals, 95% reported high satisfaction with just two treatments per year. According to RealSelf, Dysport garnered an average ‘worth it’ rating of 94%.
- Patient Satisfaction Rates with Jeuveau: Jeuveau also has high patient satisfaction rates. In a consumer survey of over 9,000 people treated with Jeuveau, 94% were satisfied with their overall treatment. Meanwhile, RealSelf reviews for Jeuveau accumulated 91% of average ‘worth it’ ratings from treated patients.
Conclusion
Dysport and Jeuveau are neuromodulator injections for aesthetics. They share similar action mechanisms, pharmacological properties, and safety profiles. However, they differ in formulation, influencing clinical efficacy and practical considerations. They effectively smooth frown lines and crow’s feet and subtly lift eyebrows.
High patient satisfaction rates show Dysport and Jeuveau’s effectiveness in wrinkle reduction. The choice between them depends on the area of concern, skin characteristics, and patient preferences. Hence, consultation with a healthcare provider is crucial to determine the optimal treatment.
FAQs
1. What are Dysport and Jeuveau?
Dysport and Jeuveau are two brand-name neuromodulator injections that utilize botulinum toxin. They are used to temporarily treat moderate to severe frown lines in adults.
2. What are the differences between Dysport and Jeuveau?
Dysport and Jeuveau have similar mechanisms of action but differ in their formulations and protein structures. Jeuveau shows swifter results due to the formulation’s use of smaller and more uniform proteins.
3. How long do the effects of Dysport and Jeuveau last?
Dysport and Jeuveau last approximately five months, with individual responses varying. Dysport may take two to three days for onset, while Jeuveau shows swifter results.
References
- 2022 Minimally Invasive Procedures. (2023). American Society of Plastic Surgeons. https://www.plasticsurgery.org/documents/News/Statistics/2022/minimally-invasive-procedure-trends-2022.pdf
- HIGHLIGHTS OF PRESCRIBING INFORMATION. (n.d.-b). In www.accessdata.fda.gov. US Food and Drug Administration. Retrieved May 4, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/761085s000lbl.pdf
