According to Testa et al. (2021), more than 10% of knee osteoarthritis (OA) patients receive intra-articular injections of different drugs, such as hyaluronic acid and platelet-rich plasma. This statistic emphasizes the interest of knee OA patients and medical professionals in managing chronic symptoms with this non-surgical solution.
The rise of intra-articular hyaluronic acid (HA) injections has emerged as a safe, effective, and long-term treatment in managing knee osteoarthritis (OA). This non-surgical treatment option offers various brand names, but Synvisc and its ingredients stand out with its three-injection therapy and Synvisc One as a single-shot solution for knee OA patients.
This article will explore the Synvisc ingredients, what each substance provides, its composition, and the overall efficacy and significance of these properties.
Key Takeaways
- Healthcare providers may recommend Synvisc injection therapy to treat knee osteoarthritis (OA) symptoms when first-line treatments have failed to adequately provide relief.
- Each ingredient in the Synvisc solution delivers a unique action that improves the effectiveness of injection therapy.
- The Synvisc ingredients include hyaluronic acid, Hylan polymers, sodium chloride, disodium hydrogen phosphate dihydrate, sodium dihydrogen phosphate dihydrate, and water for injection.
- A unique set of ingredients comprises Synvisc intra-articular injections, each contributing to the treatment’s safety and efficacy.
- When these providers understand the clinical significance of Synvisc ingredients, they can determine the best treatment option for each patient.
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Composition of Synvisc Injections
Synvisc is a viscosupplement meticulously designed to mimic the hyaluronic acid (HA) found in the joint’s synovial fluid. When medical professionals inject Synvisc directly into the affected joint, it provides lubrication and acts as a shock absorber.
Healthcare providers may recommend this injection therapy to treat knee osteoarthritis (OA) symptoms when first-line treatments have failed to provide adequate relief. Synvisc capitalizes on various ingredients to complete this effective solution. Providers can help patients determine the most suitable therapy for their knee OA concerns among Synvisc vs Cortisone or other viscosupplementation brands.
- Hyaluronic Acid: This is a naturally occurring substance in joints, skin, and eyes. It has a high capacity for retaining water and contributes to the viscoelastic properties of the synovial fluid, which helps absorb shock and lubricate the joints.
- Hylan Polymers: Hylan polymers are derivatives of hyaluronic acid that have been chemically modified to increase their molecular weight and viscosity. Hylan A is a fluid, and hylan B is a gel, creating a mixture resembling natural synovial fluid in the knee joint.
- Sodium Chloride: Commonly known as salt, Synvisc uses sodium chloride in the injection solution to maintain the osmotic balance with the body’s natural fluids. It ensures that the solution does not dehydrate or overhydrate the surrounding tissues.
- Disodium Hydrogen Phosphate Dihydrate: This salt buffers the solution, helping to maintain a stable pH level compatible with the body’s natural environment and minimizing irritation and discomfort upon injection.
- Sodium Dihydrogen Phosphate Dihydrate: Like disodium hydrogen phosphate dihydrate, this salt acts as a buffer. It works with other buffering agents to maintain the pH balance of the Synvisc solution.
- Water for Injection: This is highly purified, sterile water that serves as the solvent for all the ingredients in the Synvisc injection. The injection ensures its fluidity for administration and even distribution of the active ingredients.
Mode of Action of Synvisc Injection and Its Ingredients
Synvisc or Synvisc One dosage injections derive their hyaluronic acid (HA) from chicken combs. The injection therapy supplements the natural synovial fluid in the knee joint, improves its viscoelastic properties, and provides lubrication and cushioning.
Hyaluronic acid is a critical component of synovial fluid. Its mechanism of action in the joint includes binding to water molecules, which enhances the fluid’s ability to lubricate and absorb shocks, thereby reducing pain and improving joint function. Furthermore, each ingredient in the Synvisc solution delivers a unique action for the injection.
- Role of Hylan Polymers in Joint Lubrication: Chemical modification has made Hylan polymers last longer. They play a role in joint lubrication by forming a layer on the cartilage surfaces, reducing friction and wearing down.
- Osmotic Effects of Sodium Chloride: Sodium chloride in the Synvisc formulation helps maintain the synovial fluid’s pressure, ensuring it retains the necessary water content for adequate joint lubrication and cushioning.
- Buffering Effects of Disodium Hydrogen Phosphate Dihydrate and Sodium Dihydrogen Phosphate Dihydrate: These salts act as buffers to maintain the pH of the Synvisc injection, ensuring stability and compatibility with the body’s tissues.
- Importance of Water: Water is a solvent for Synvisc injections, dissolving the active ingredients and facilitating their administration into the knee joint.
With all these Synvisc ingredients, it’s worth noting that patients should discuss this information with their healthcare professionals for personalized medical advice and comprehensive knowledge about the treatment.
Clinical Significance of Synvisc Ingredients
Medical professionals should discuss Synvisc treatment, formulation, benefits, and potential risks with patients to help them understand the therapy. When these providers understand the clinical significance of Synvisc ingredients, they can determine the best treatment option for each patient.
Hyaluronic acid has proven effective in retaining water and allowing pain-free joint movements. It efficiently lubricates and cushions the joints, reducing pain and improving mobility in knee osteoarthritis (OA) patients.
The cross-linked Hylan polymers provide a durable and resilient supplement to the synovial fluid. Synvisc offers a longer-lasting significant improvement in knee OA relief. Meanwhile, sodium chloride in Synvisc knee injections ensures the solution’s compatibility with the body’s fluids.
The Synvisc formulation contains phosphate buffers to maintain the injection’s pH balance. These properties ensure the stability of the active Synvisc ingredients. Moreover, the water clears the solution from contaminants, making Synvisc a safe and effective intra-articular injection.
Conclusion
A unique set of ingredients comprises Synvisc intra-articular injections, each contributing to the treatment’s safety and efficacy. Synvisc injection primarily relies on the potency of hyaluronic acid derivatives – hylan polymers. In addition, sodium chloride, phosphate buffers, and water are crucial in lubrication and shock absorption for the joints.
When injected into the affected joint, Synvisc supplements the natural hyaluronic acid in the synovial fluid, providing symptomatic relief. Understanding the Synvisc ingredients and their function can help medical professionals ensure a safe, effective, patient-centric Synvisc treatment.
FAQs
1. What is Synvisc?
Synvisc is a viscosupplement mimicking the hyaluronic acid in the joint’s synovial fluid. It is an intra-articular injection to treat knee osteoarthritis (OA) symptoms.
2. What are the ingredients of Synvisc?
The Synvisc ingredients include hyaluronic acid, Hylan polymers, sodium chloride, disodium hydrogen phosphate dihydrate, sodium dihydrogen phosphate dihydrate, and water for injection.
3. How does Synvisc work?
Synvisc supplements the natural synovial fluid in the knee joint, improves its viscoelastic properties, and provides lubrication and cushioning. Its mechanism of action involves binding to water molecules, reducing pain, and improving joint function.
4. What is the clinical significance of Synvisc ingredients?
The clinical significance of Synvisc ingredients lies in their ability to provide an effective and long-term solution to manage knee osteoarthritis (OA) symptoms. Synvisc’s ingredients improve lubrication, cushioning, and joint function. However, patients should always discuss this treatment with their healthcare professionals for personalized medical advice.
References
- Testa, G., Giardina, S. M. C., Culmone, A., Vescio, A., Turchetta, M., Cannavò, S., & Pavone, V. (2021). Intra-Articular Injections in Knee Osteoarthritis: A Review of Literature. Journal of Functional Morphology and Kinesiology, 6(1), 15. https://doi.org/10.3390/jfmk6010015
- Instructions For Use Synvisc® (hylan G-F 20). (n.d.). Sanofi CA. Retrieved May 2, 2024, from https://products.sanofi.ca/en/Synvisc-Information-for-Use.pdf
